Translational Neuro-Oncology

Research Lab

Operating Room Discussion

Neurosurgical Oncology

We aim to identify the molecular genetic alterations that underlie the development, progression and treatment resistance of brain tumors. By understanding the mechanism by which tumor genome alterations drive the growth of these cancers, therapeutic strategies can be designed to improve outcomes for patients.

The lab's current research effort aims at characterizing the response of brain tumors to targeted therapeutics, in particular examining the IDH mutant subclass of malignant gliomas.  IDH mutant gliomas (consisting of oligodendrogliomas, astrocytomas, and secondary glioblastomas - approximately 20-25% of adult diffuse gliomas) are a distinct genomic subset of cancers that arise via a different pathway of tumor evolution when compared to other types of brain tumors.  They have discrete mutations, metabolic phenotypes, and vulnerabilities to standard (surgery, radiation) and experimental (targeted) therapy.  Our group is actively involved in many different studies of these tumors.

Our broader research effort has contributed to single-cell sequencing, genomic analyses of other CNS tumor sub-types such as craniopharyngioma, meningioma, brain metastases, hemangioblastoma, and spinal cord astrocytomas.  In the past, we have made key discoveries regarding the molecular mechanisms of chemoresistance in human glioblastomas, as combined radiation and alkylating chemotherapy temozolomide have become the standard-of-care for patients over the last decade.

 

 
Daniel P. Cahill, MD, PhD
Neurosurgeon
Physician Profile
Phone: 617-724-0884

Publications
Publications

Selected Publications

Daniel P. Cahill, III, MD PhD

  1. Shankar GM, Francis JM, Rinne ML, Ramkissoon SH, Huang FW, Venteicher AS, Akama-Garren EH, Kang YJ, Lelic N, Kim JC, Brown LE, Charbonneau SK, Golby AJ, Sekhar Pedamallu C, Hoang MP, Sullivan RJ, Cherniack AD, Garraway LA, Stemmer-Rachamimov A, Reardon DA, Wen PY, Brastianos PK, Curry WT, Barker FG, Hahn WC, Nahed BV, Ligon KL, Louis DN, Cahill DP, Meyerson M. Rapid Intraoperative Molecular Characterization of Glioma. JAMA Oncol. 2015 Aug 1; 1(5):662-7.
    View in: PubMed
  2. Juratli TA, Cahill DP, McCutcheon IE. Determining optimal treatment strategy for diffuse glioma: the emerging role of IDH mutations. Expert Rev Anticancer Ther. 2015 Jun; 15(6):603-6.
    View in: PubMed
  3. Brastianos PK, Cahill DP. Management of brain metastases in the era of targeted and immunomodulatory therapies. Oncology (Williston Park). 2015 Apr; 29(4):261-3.
    View in: PubMed
  4. Jones PS, Cahill DP, Brastianos PK, Flaherty KT, Curry WT. Ipilimumab and craniotomy in patients with melanoma and brain metastases: a case series. Neurosurg Focus. 2015 Mar; 38(3):E5.
    View in: PubMed
  5. Olar A, Wani KM, Alfaro-Munoz KD, Heathcock LE, van Thuijl HF, Gilbert MR, Armstrong TS, Sulman EP, Cahill DP, Vera-Bolanos E, Yuan Y, Reijneveld JC, Ylstra B, Wesseling P, Aldape KD. IDH mutation status and role of WHO grade and mitotic index in overall survival in grade II-III diffuse gliomas. Acta Neuropathol. 2015 Apr; 129(4):585-96.
    View in: PubMed
  6. Brastianos HC, Cahill DP, Brastianos PK. Systemic therapy of brain metastases. Curr Neurol Neurosci Rep. 2015 Feb; 15(2):518.
    View in: PubMed
  7. Shankar GM, Taylor-Weiner A, Lelic N, Jones RT, Kim JC, Francis JM, Abedalthagafi M, Borges LF, Coumans JV, Curry WT, Nahed BV, Shin JH, Paek SH, Park SH, Stewart C, Lawrence MS, Cibulskis K, Thorner AR, Van Hummelen P, Stemmer-Rachamimov AO, Batchelor TT, Carter SL, Hoang MP, Santagata S, Louis DN, Barker FG, Meyerson M, Getz G, Brastianos PK, Cahill DP. Sporadic hemangioblastomas are characterized by cryptic VHL inactivation. Acta Neuropathol Commun. 2014; 2(1):2.
    View in: PubMed
  8. Taylor JW, Dietrich J, Gerstner ER, Norden AD, Rinne ML, Cahill DP, Stemmer-Rachamimov A, Wen PY, Betensky RA, Giorgio DH, Snodgrass K, Randall AE, Batchelor TT, Chi AS. Phase 2 study of bosutinib, a Src inhibitor, in adults with recurrent glioblastoma. J Neurooncol. 2015 Feb; 121(3):557-63.
    View in: PubMed
  9. Loebel F, Cahill DP, Bogner W, Marjanska M, Gerstner E, Batchelor T, Rosen BR, Chi AS, Andronesi OC. Sherry apple resident travel scholarship 194 assessment of treatment response in isocitrate dehydrogenase-mutant gliomas by quantification of 2-hydroxyglutarate with in vivo 3-dimensional magnetic resonance spectroscopy. Neurosurgery. 2014 Aug; 61 Suppl 1:224.
    View in: PubMed
  10. Patel AP, Tirosh I, Trombetta JJ, Shalek AK, Gillespie SM, Wakimoto H, Cahill DP, Nahed BV, Curry WT, Martuza RL, Louis DN, Rozenblatt-Rosen O, Suvà ML, Regev A, Bernstein BE. Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science. 2014 Jun 20; 344(6190):1396-401.
    View in: PubMed
  11. Ginat DT, Swearingen B, Curry W, Cahill D, Madsen J, Schaefer PW. 3 Tesla intraoperative MRI for brain tumor surgery. J Magn Reson Imaging. 2014 Jun; 39(6):1357-65.
    View in: PubMed
  12. Kim BY, Jiang W, Beiko J, Prabhu SS, DeMonte F, Gilbert MR, Sawaya R, Aldape KD, Cahill DP, McCutcheon IE. Diagnostic discrepancies in malignant astrocytoma due to limited small pathological tumor sample can be overcome by IDH1 testing. J Neurooncol. 2014 Jun; 118(2):405-12.
    View in: PubMed
  13. Suvà ML, Rheinbay E, Gillespie SM, Patel AP, Wakimoto H, Rabkin SD, Riggi N, Chi AS, Cahill DP, Nahed BV, Curry WT, Martuza RL, Rivera MN, Rossetti N, Kasif S, Beik S, Kadri S, Tirosh I, Wortman I, Shalek AK, Rozenblatt-Rosen O, Regev A, Louis DN, Bernstein BE. Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells. Cell. 2014 Apr 24; 157(3):580-94.
    View in: PubMed
  14. Wakimoto H, Tanaka S, Curry WT, Loebel F, Zhao D, Tateishi K, Chen J, Klofas LK, Lelic N, Kim JC, Dias-Santagata D, Ellisen LW, Borger DR, Fendt SM, Vander Heiden MG, Batchelor TT, Iafrate AJ, Cahill DP, Chi AS. Targetable signaling pathway mutations are associated with malignant phenotype in IDH-mutant gliomas. Clin Cancer Res. 2014 Jun 1; 20(11):2898-909.
    View in: PubMed
  15. Simon MV, Sheth SA, Eckhardt CA, Kilbride RD, Braver D, Williams Z, Curry W, Cahill D, Eskandar EN. Phase reversal technique decreases cortical stimulation time during motor mapping. J Clin Neurosci. 2014 Jun; 21(6):1011-7.
    View in: PubMed
  16. Beiko J, Suki D, Hess KR, Fox BD, Cheung V, Cabral M, Shonka N, Gilbert MR, Sawaya R, Prabhu SS, Weinberg J, Lang FF, Aldape KD, Sulman EP, Rao G, McCutcheon IE, Cahill DP. IDH1 mutant malignant astrocytomas are more amenable to surgical resection and have a survival benefit associated with maximal surgical resection. Neuro Oncol. 2014 Jan; 16(1):81-91.
    View in: PubMed
  17. Huse JT, Wallace M, Aldape KD, Berger MS, Bettegowda C, Brat DJ, Cahill DP, Cloughesy T, Haas-Kogan DA, Marra M, Miller CR, Nelson SJ, Salama SR, Soffietti R, Wen PY, Yip S, Yen K, Costello JF, Chang S. Where are we now? And where are we going? A report from the Accelerate Brain Cancer Cure (ABC2) low-grade glioma research workshop. Neuro Oncol. 2014 Jan; 16(2):173-8.
    View in: PubMed
  18. Andronesi OC, Rapalino O, Gerstner E, Chi A, Batchelor TT, Cahill DP, Sorensen AG, Rosen BR. Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate. J Clin Invest. 2013 Sep 3; 123(9):3659-63.
    View in: PubMed
  19. Bhat KP, Balasubramaniyan V, Vaillant B, Ezhilarasan R, Hummelink K, Hollingsworth F, Wani K, Heathcock L, James JD, Goodman LD, Conroy S, Long L, Lelic N, Wang S, Gumin J, Raj D, Kodama Y, Raghunathan A, Olar A, Joshi K, Pelloski CE, Heimberger A, Kim SH, Cahill DP, Rao G, Den Dunnen WF, Boddeke HW, Phillips HS, Nakano I, Lang FF, Colman H, Sulman EP, Aldape K. Mesenchymal differentiation mediated by NF-?B promotes radiation resistance in glioblastoma. Cancer Cell. 2013 Sep 9; 24(3):331-46.
    View in: PubMed
  20. Taylor JW, Chi AS, Cahill DP. Tailored therapy in diffuse gliomas: using molecular classifiers to optimize clinical management. Oncology (Williston Park). 2013 Jun; 27(6):504-14.
    View in: PubMed
  21. Shonka NA, Theeler B, Cahill D, Yung A, Smith L, Lei X, Gilbert MR. Outcomes for patients with anaplastic astrocytoma treated with chemoradiation, radiation therapy alone or radiation therapy followed by chemotherapy: a retrospective review within the era of temozolomide. J Neurooncol. 2013 Jun; 113(2):305-11.
    View in: PubMed
  22. Jones PS, Dunn GP, Barker FG, Curry WT, Hochberg FH, Cahill DP. Molecular genetics of low-grade gliomas: genomic alterations guiding diagnosis and therapeutic intervention. 11th annual Frye-Halloran Brain Tumor Symposium. Neurosurg Focus. 2013 Feb; 34(2):E9.
    View in: PubMed
  23. Dunn GP, Andronesi OC, Cahill DP. From genomics to the clinic: biological and translational insights of mutant IDH1/2 in glioma. Neurosurg Focus. 2013 Feb; 34(2):E2.
    View in: PubMed

 


Investigators
Investigators

Biographies

Daniel P. Cahill, MD, PhD

As a neurosurgeon-scientist, Dr. Cahill's clinical practice is highly-focused on the care of brain tumor patients, improving national clinical trials of therapy for these patients, and training neurosurgical residents to surgically diagnose and treat these cancers.

Dr. Cahill was born and raised in Connecticut, attending Yale College and then Johns Hopkins Medical School in Baltimore, receiving his MD/PhD degrees in 2001.  He completed neurosurgery residency training at the Massachusetts General Hospital in 2008.  His first faculty position was in the practice of neurosurgical oncology at MD Anderson Cancer Center in Houston.  He then rejoined the faculty of the MGH Brain Tumor Center in 2011, where he is currently in active practice.

 

Daniel P. Cahill, MD, PhD
Laboratory Director
MGH Physician Profile
Phone: 617-724-0884
Fax: 617- 724-0887

Research Team
Open Positions

Research Positions

Neurosurgical Oncology

Postdoctoral MD or PhD research fellowships are typically arranged 1-to-2 years prior to the anticipated start date, to allow for adequate funding support covering the training years.  On occasion, internships for undergraduates and medical students are sometimes available in this lab.  

For information please contact Dr. Cahill.

Daniel P. Cahill, MD, PhD

MGH Physician Profile
Phone: 617-724-0884
Fax: 617- 724-0887

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